Keeping healthy is just as important as all other things that children are taught to be great at. Keeping healthy will help kids to grow strong bodies and minds. Furthermore, developing healthy habits at the early age is more likely to be continued into adulthood. Back to school is time to optimize health and get back to routine. Setting up sleep and nutrition routines helps with happier, healthier transition.
Proper nutrition, diet, physical activity, balanced immune system, and cognitive health are some of the key factors to start and maintain a healthy school year.
Keep healthy with optimized nutrition:
The key concerning nutrients for children and teens are Iron, Calcium, Vitamin D, Vitamin A, Omega 3 fatty acids. Taking a high quality multivitamin ensures your kids and teens are getting their basic nutrients. Omega 3 is the nourishes the brain, modulates immune system, and helps with balancing hormones and mood in teens.
Maintain a healthy immune system:
Common cold is a leading cause of medical visits and missed days at work or school. The common cold is a viral infection of the upper respiratory tract that causes symptoms such as a runny or stuffy nose, sneezing, coughing, and sore throat. Systemic symptoms such as mild headache, fatigue, fever, and muscle aches can also occur with the common cold. When these symptoms are severe and/or accompanied by fever or significant exhaustion, they likely indicate the "flu", which is a different type of viral respiratory infection caused by an influenza virus. Treatment for the common cold are generally to relieve symptoms, shorten duration, and minimize the risk of complications.
Science based evidence show that nutrients such as vitamin D, vitamin C, zinc, and natural compounds including beta glucan and lactoferrin, medecinal herbs like Astragalus, Echinacea, and elderberry as well as probiotics help manage symptom duration and intensity associated with the common cold.
Evidently vitamin D has a significant role in the regulating human immune system, and may reduce the risk of certain bacterial and viral infections. Theories suggests that vitamin D supplementation may help body to produce a compound known as cathelicidin which is a naturally occurring antimicrobial and antiviral which is useful against respiratory infections such as the common cold. Plus there is link between higher vitamin D levels and decreased risk of contracting a seasonal viral infection.
Studies suggest Vitamin C enhances the production and action of white blood cells; for instance it increases the ability of neutrophil white blood cells to fight off viruses. Vitamin C has been shown to reduce the chances of catching a cold, and may reduce cold duration. Date from clinical studies, found that using vitamin C (1000 mg) plus zinc (10 mg) during a cold could reduce runny nose symptoms by up to 27 % over 5 days of treatment compared to placebo. Zinc helps maintain a healthy immune system. Zinc deficiency is common and affects approximately 2 billion people worldwide. Correcting zinc deficiency through supplementation is shown to improve the immune system. Zinc prevents the attachment of rhinovirus to cells in the nasal passages; furthermore, it prevents viral replication, reduces histamine release, and inhibits the production of other inflammatory markers.
Astragalus membranaceus contains a number of immune-stimulating compounds which have been researched for their application for treating immune deficiency conditions. In a clinical study which compared different natural products including echinacea, astragalus membranaceus, and licorice, Astragalus membranaceus demonstrated the strongest ability to activate immune cells.
Elderberry, also known as Sambucus nigra is a rich source of antioxidants and today, elderberry extract is employed to manage different types of viral infections such as common cold. Researchers believe that elderberry can activate white blood cells. The German Commission E (a therapeutic guide for the safety and efficacy of herbal products) has identified the constituents of elderberry as effective for the relief of colds.
Echinacea is one of the most popular herbs used for the treatment and prevention of upper respiratory tract infections such as the common cold. Clinical evidence is indicative of echinacea being able to reduced severity and duration of cold symptoms, as well as to increase total white blood cell count.
Lactoferrin is an iron-binding protein in milk, which is also a powerful immune modulator. Lactoferrin has shown to fight bacteria, fungi, protozoa, and viruses. In vitro studies found that lactoferrin could inhibit the ability of certain viruses to bind to cell receptor sites.
Beta-glucans are naturally occurring compound of the certain plants' and mushrooms cell wall. These polysaccharides have been shown to increase immune defense, enhancing macrophage and natural killer cell function. Beta glucans are found to be able to inhibit the common cold symptoms. In studies, those participants who consumed beta-glucans had 23% fewer upper respiratory tract infections, compared to the placebo group.
An allergy is results of a profound immune respond to a harmless environmental substance. Epidemiological studies shows that the number of allergic diseases has increased worldwide over the last few decades. Allergic diseases include atopic dermatitis, allergic rhinitis, asthma, food, drug and insect allergy, urticaria or hives and angioedema which is swelling beneath the skin.
Common inhaled allergens include tree and flower pollen, animal dander, dust, and mold. Ingested allergens include medications and foods such as eggs, peanuts, wheat, tree nuts, and shellfish. High levels of certain elements such as nickel, copper can also cause allergies.
These allergens may affect different parts of the body. Common Symptoms of allergies include itching, stuffy and/or runny nose, postnasal drip, facial pressure, pain, tingling sensation in the mouth, swollen mouth and lips, itchy throat, irritated eyes, respiratory conditions such as wheezing, coughing, difficulty breathing, shortness of breath, skin irritations, hives, rashes, and gastrointestinal symptoms stomach like cramps, vomiting, and diarrhea. These symptoms can occur within minutes to days after exposure and can range from mild to severe.
Use of antibiotics along with the widespread use of antimicrobial agents in consumer products like soap have reduced disturbs the microflora balance. Various studies suggest that the use of probiotics provide significant clinical benefits to modulate immune health and reduce frequency and severity of the allergic reactions.
Probiotics containing Lactobabillus casei decreased the frequency and severity of nose and eye symptoms and improved the quality of preschool children with seasonal allergic rhinitis. Clinical trial suggests that BB536 favorably modulated intestinal microbiotia, lessening the burden of allergens, in subjects with cedar pollen allergies. Other clinical studies on L. plantarum showed that it is effective in reducing eosinophil (specialized white blood cells which response to allergies) counts decreased immediately after intake in the group. Also, there are plenty of studies which are indicative of beneficial use of probiotics such as Lactobacillus rhamnosus GG (LGG) and supplemental probiotics mixture in prevention and treatment of allergic conditions including atopic dermatitis and food sensitivities such as cow milk.
Vitamin D plays an important role in modulating immune system and, in particular, allergic diseases. It is well known that vitamin D receptors are found in variety of tissues and cells in the human body, including immune cells which are important in the recognition of antigens. Vitamin D also has multiple cytokine-modulating effects. This vitamin has also been shown to have a role in airway remodeling, which may be important in managing asthma. Molecular studies provide evidence that vitamin D can regulate inflammatory responses, enhance antimicrobial peptide activity and promote the integrity of the permeability of the skin.
Vitamin D deficiency is associated with an increased incidence of asthma and allergy symptoms, higher IgE responses to food and environmental allergens in children and adults.
Vitamin E is a fat-soluble vitamin that acts as a free-radical scavenger and it also has been shown to inhibit the activation of neutrophils – cells that contribute to respiratory inflammation in asthma. Several studies provide evidence of the link between vitamin E intake and asthma or allergic diseases. A case-control studies reported that childhood asthma is associated with low dietary vitamin E intake. In a clinical study of atopic dermatitis, patients who were given oral supplement of 400 IU vitamin E daily for 8 months reported remarkable improvement in facial redness, scaling and thickening of the skin; Furthermore, their eczema lesions healed quicker as due to less itchiness of the skin.
Vitamin C (ascorbic acid) is an antioxidant which protects the cells against free radicals, it is able to improve the function of many immune cells, and it provides antihistamine properties which may help relieve allergy symptoms. Animal studies showed that high dose vitamin C supplementation greatly reduced lung inflammation.
Magnesium is utilized by every cell in the body and participates in at least 350 enzymatic processes within the body. Evidence based studies suggest that magnesium plays a role in immune response, and that deficiency may contribute to increased inflammation. Supplementation with taking 200 - 290 mg of magnesium daily for 16 weeks significantly reduced the use of bronchodilators in children with mild to moderate asthma. More recently, long term treatment with oral magnesium (170 mg twice a day for 6.5 months) in adults with mild to moderate asthma showed improvement in objective measures of bronchial reactivity and quality of life.
Studies suggest that the omega-3 fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid reduce the production of inflammatory cytokines which are involved in the allergic response.
Quercetin, one of the most common flavonoids found in a variety of foods and has been extensively studied for its ability to reduce allergic symptoms. It has been shown to reduce the release of histamine from mast cells, also it is shown to suppress the inflammatory response of immune cells upon antigen recognition.
Patients with nasal allergies treated with quercetin experienced rapid and significant relief of nasal symptoms that was comparable to antihistamine preparations. In two independent randomized controlled studies on individuals with pollen allergies, taking 100 mg of a quercetin-related compound for 8 weeks, greatly reduced nasal symptoms compared to placebo group.
Keep a healthy brain and mood:
Integrative medicine has been shown to effectively improve brain health and help to maintain focus, attention, and cognitive health. For example, data from studies suggest that supplementation with omega-3 fatty acids, Phosphatidylserine (PS), Acetyl-L-carnitine, vitamin B6 and magnesium to be beneficial for those affected by attention disorders.
Nutritional deficiencies, brain injury, environmental toxins, and diet are the main contributors to the brain health, memory, learning, and focus. Studies indicate that children who eat a balanced breakfast containing proteins, vitamins, and minerals have better attention level during morning hours at school.
Hyperactivity and poor attention in general are linked to omega-3 deficiency. A comprehensive review by researchers at Yale University found that supplementation with omega-3 fatty acids modestly improved symptoms of attention disorders.
Phosphatidylserine (PS) is a major part of cell membranes and is considered one of the most important brain nutrients. PS has a variety of functions within the brain including supporting cell membrane fluidity and beneficially influencing neurotransmitter systems. Results from several clinical trials indicate that PS improves symptoms of inattention, impulsive, and short-term memory. PS is well tolerated and No adverse effects were reported.
Acetyl-L-carnitine is a natural derivative of L-carnitine. Acetyl-L-carnitine plays a key role in the metabolism of fatty acids and cellular energy production. Randomized, double-blind trials, found Acetyl-L-carnitine to have a beneficial effect on cognition, hyperactivity and social behavior.
Both magnesium and vitamin B6 deficiency have been observed in children with attention disorders. A study on 40 participants found that supplementation with magnesium and vitamin B6 led to improvements in hyperactivity and school attention; although when the treatment was discontinued, the children’s symptoms reappeared in a few weeks.
Zinc and iron are involved in dopamine production, so deficiencies in these minerals could impact dopamine neurotransmission. For example a great number of kids with ADHD are Iron deficient and the severity of the iron deficiency is related to the severity of symptoms.
Adequate sleep quantity and quality are important for brain health and performance. Improving sleep has shown reduce symptoms of attention disorder. Sleep is also known to modulate the immune response.
Physical activity or exercise may have a positive impact on cognitive health in both adults and children. Studies on individuals with ADHD suggest frequent aerobic exercise significantly decrease in impulsive symptoms and anxiety. Another study showed that cognitive symptoms in children with ADHD were improved after just twenty minutes of moderate exercise.
Lifestyle factors to keep fit and healthy during school:
Physical activity helps prevent childhood obesity, it improves muscle growth, brain health and development. Nowadays, easy access to technology and smart devices although helps to improve learning , prevents kids from being active. Research suggest that the childhood obesity should be considered an independent risk factor for adult obesity, and metabolic disorders.
Positive eating behaviours helps to prevent emotional eating. It is important to know that food should not be used as reward. Children's diet should include verity of healthy foods, fresh vegetables, proteins, whole grain, nuts, fresh fruits, diary, and dairy alternatives.
- How to Boost Memory and Brain Health?
- Nutrients And Their Life Changing Effects On Brain Health
- Natural Solutions to Quick Recovery from Common Cold
- Allergies & Natural Ways of Relief
1.American Academy of Allergy, Asthma and Immunology. Allergies. Available at http://www.aaaai.org/conditions-and-treatments/al... Accessibility verified December 17, 2011.
2.Asher MI, Montefort S, ISAAC Phase Three Study Group, et al. Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys. Lancet. 2006 Aug 26;368(9537):733-43.
3.Bahna SL. Clinical expressions of food allergy. Ann Allergy Asthma Immunol. 2003 Jun;90(6 Suppl 3):41-4.
4.Bede O, Surányi A, Pintér K, Szlávik M, Gyurkovits K. Urinary magnesium excretion in asthmatic children receiving magnesium supplementation: a randomized, placebo-controlled, double-blind study. Magnes Res. 2003 Dec;16(4):262-70.
5.Bellanti JA. Cytokines and allergic diseases: clinical aspects. Allergy Asthma Proc 1998 Dec;19(6):337-41.
6.Berni Canani R, Nocerino R, Terrin G, et al. Effect of Lactobacillus GG on tolerance acquisition in infants with cow's milk allergy: A randomized trial. J Allergy ClinImmunol. 2011 Nov 10.
7.Björkstén B, Clayton T, et al. ISAAC Phase III Study Group. Worldwide time trends for symptoms of rhinitis and conjunctivitis: Phase III of the International Study of Asthma and Allergies in Childhood. Pediatr Allergy Immunol. 2008 Mar;19(2):110-24.
8.Bousquet J, Khaltaev N, Cruz AA, Denburg J, et al. Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen). Allergy. 2008 Apr;63Suppl 86:8-160.
9.Branum AM, Lukacs SL. Food allergy among U.S. children: trends in prevalence and hospitalizations. NCHS Data Brief. 2008 Oct;(10):1-8.
10.Bucca C, Rolla G, et al. Effect of vitamin C on histamine bronchial responsiveness of patients with allergic rhinitis. Ann Allergy . 1990 Oct; 65(4):311–4.
11.Calder PC. N-3 polyunsaturated fatty acids, inflammation and immunity: pouring oil on troubled waters or another fishy tale? Nutr Res . 2001;21:309–41.
12.Calder PC. Polyunsaturated fatty acids and inflammation. BiochemSoc Trans . 2005 Apr; (pt 2): 423–7.
13.Camargo CA, RifasShiman SL, Litonjua AA, et al. Maternal intake of vitamin D during pregnancy and risk of recurrent wheeze in children at 3 y of age. Am J ClinNutr 2007;85:788–795
14.Casas IA , DobrogoszWJ. Validation of the probiotic concept: Lactobacillus reuteri confers broad-spectrum protection against disease in humans and animals. Microbial Ecology in Health and Disease 2000;12:247–85.
15.CederholmTE et al. Low levels of essential fatty acids are related to impaired delayed skin hypersensitivity in malnourished chronically ill elderly people. Eur J Clin Invest. 1994 Sep;24(9):615-20.
16.Centanni S, Santus P, Di Marco F, et al. The potential role of tocopherol in asthma and allergies: modification of the leukotriene pathway. Biodrugs . 2001;15(2):81–6.
17.Chang HH, Chen CS, Lin JY. High dose vitamin C supplementation increases the Th1/Th2 cytokine secretion ratio, but decreases eosinophilic infiltration in bronchoalveolar lavage fluid of ovalbumin-sensitized and challenged mice. J Agric Food Chem. 2009 Nov 11;57(21):10471-6.
18.Chinellato I, Piazza M, Sandri M, et al. Vitamin D serum levels and markers of asthma control in Italian children. J Pediatr 2011;158:437–441.
19.Chirumbolo S, Marzotto M, Conforti A, et al.Bimodal action of the flavonoid quercetin on basophil function: an investigation of the putative biochemical targets. ClinMol Allergy. 2010 Sep 17;8:13.
20.Choi SH, Yoo Y, Yu J, et al. Bronchial hyperresponsiveness in young children with allergic rhinitis and its risk factors. Allergy. 2007 Sep;62(9):1051-6.
21.Ciarallo L, Brousseau D, Reinert S. Higher-dose intravenous magnesium therapy for children with moderate to severe acute asthma. Arch PediatrAdolesc Med. 2000 Oct;154(10):979-83.
22.Ciarallo L, Sauer AH, Shannon MW. Intravenous magnesium therapy for moderate to severe pediatric asthma: results of a randomized, placebo-controlled trial. J Pediatr. 1996;129(6):809–14.
23.Clifford RL, Knox AJ. Vitamin D-a new treatment for airway remodelling in asthma?. Br J Pharmacol 2009;158:1426–1428.
24.Connor WE. N-3 Fatty acids from fish and fish oil: panacea or nostrum? Am J ClinNutr. 2001;74:415 – 6.
25.Craig TJ, Sherkat A, Safaee S. Congestion and sleep impairment in allergic rhinitis. Curr Allergy Asthma Rep. 2010 Mar;10(2):113-21.
26.Devi PR, Kumar L, Singhi SC, Prasad R, Singh M. Intravenous magnesium sulfate in acute severe asthma not responding to conventional therapy. Indian Pediatr. 1997;34(5):389–97.
27.Freishtat RJ, Iqbal SF, Pillai DK, et al. High prevalence of vitamin d deficiency among inner-city African American youth with asthma in Washington, DC. J Pediatr 2010;156:948– 952.
28.GerasimovSV, VasjutaVV, MyhovychOO, Bondarchuk LI. Probiotic supplement reduces atopic dermatitis in preschool children: a randomized, double-blind, placebo-controlled, clinical trial. Am J ClinDermatol. 2010;11(5):351-61.
29.Goldin BR. Health benefits of probiotics. Br J Nutr1998;80:S203–S207 .
30.Gontijo-Amaral C, Ribeiro MA, GontijoLS, Condino-Neto A, Ribeiro JD. Oral magnesium supplementation in asthmatic children: a double-blind randomized placebo-controlled trial. Eur J ClinNutr. 2007 Jan;61(1):54-60. Epub 2006 Jun 21.
31.Gun F, Salman T, et al. Effect of probiotic supplementation on bacterial transaction in thermal injury. Surg Today . 2005;35(9):760–4.
32.Guo R, Pittler MH, Ernst E. Herbal medicines for the treatment of allergic rhinitis: a systematic review. Ann Allergy Asthma Immunol. 2007 Dec;99(6):483-95.
33.Gupta R, Sheikh A, Strachan DP, Anderson HR. Burden of allergic disease in the UK: secondary analyses of national databases. ClinExp Allergy. 2004 Apr;34(4):520-6.
34.Gürkan F, Haspolat K, Bosnak M, et al. Intravenous magnesium sulphate in the management of moderate to severe acute asthmatic children nonresponding to conventional therapy. Eur J Emerg Med. 1999;6(3):201–5.
35.Hansen I, Klimek L, Mosges R, Hormann K. Mediators of inflammation in the early and the late phase of allergic rhinitis. CurrOpin Allergy ClinImmunol. 2004 Jun;4(3):159-63.
36.Hijazi N, Abalkhail B, et al. Diet and childhood asthma in a society in transition: A study in urban and rural Saudi Arabia . Thorax . 2000 Sep;55(9):775–9.
37.Hirano T, Kawai M, Arimitsu J, et al. Preventative effect of a flavonoid, enzymatically modified isoquercitrin on ocular symptoms of Japanese cedar pollinosis. Allergol Int. 2009 Sep;58(3):373-82. Epub 2009 May 25.
38.Hollams EM, Hart PH, Holt BJ, et al. Vitamin D and atopy and asthma phenotypes in children: a longitudinal cohort study. EurRespir J. 2011 Dec;38(6):1320-7. Epub 2011 May 12.
39.Huang RY, Yu YL, Cheng WC, et al. Immunosuppressive effect of quercetin on dendritic cell activation and function. J Immunol. 2010 Jun 15;184(12):6815-21. Epub 2010 May 17.
40.Javanbakht MH, Keshavarz SA, Djalali M, et al. Randomized controlled trial using vitamins E and D supplementation in atopic dermatitis. J Dermatolog Treat. 2011 Jun;22(3):144-50. Epub 2010 Jul 24.
41.Jedrychowski W et al. Wheezing and asthma may be enhanced by broad spectrum antibiotics used in early childhood. Concept and results of a pharmacoepidemiology study. J PhysiolPharmacol. 2011 Apr;62(2):189-95.
42.Johnston CS, Solomon RE, Corte C. Vitamin C depletion is associated with alterations in blood histamine and plasma free carnitine in adults. J Am CollNutr . 1996 Dec;15(6):586–91.
43.Joskova M, Franova S, Sadlonova V. Acute bronchodilator effect of quercetin in experimental allergic asthma. BratislLekListy. 2011;112(1):9-12.
44.Kalliomaki M, Kirjavainen P, Eerola E, et al. Distinct patterns of neonatal gut microflora in infants in whom atopy was and was not developing. J Allergy ClinImmunol 2001;107:129–34.
45.Kawai M, Hirano T, Arimitsu J, et al.Effect of enzymatically modified isoquercitrin, a flavonoid, on symptoms of Japanese cedar pollinosis: a randomized double-blind placebo-controlled trial. Int Arch Allergy Immunol. 2009;149(4):359-68. Epub 2009 Mar 17.
46.Kazaks AG, Uriu-Adams JY, Albertson TE, Shenoy SF, Stern JS. Effect of oral magnesium supplementation on measures of airway resistance and subjective assessment of asthma control and quality of life in men and women with mild to moderate asthma: a randomized placebo controlled trial. J Asthma. 2010 Feb;47(1):83-92.
47.Kelly D, Conway S. Bacterial modulation of mucosal innate immunity. Molecular Immunology. 2005;42(8):895–901.
48.Kelly D, King T, Aminov R. Importance of microbial colonization of the gut in early life to the development of immunity. Mutation Research. 2007;622(1-2):58–69.
49.Kempna P, Reiter E, Arock M, Azzi A, Zingg JM. Inhibition of HMC-1 mast cell proliferation by vitamin E: involvement of the protein kinase B pathway. J BiolChem 2004;279:50700-9.
50.Klemens CM, Berman DR, Mozurkewich EL. The effect of perinatal omega-3 fatty acid supplementation on inflammatory markers and allergic diseases: a systematic review. BJOG. 2011 Jul;118(8):916-25. .
51.Laires MJ, Monteiro C. Exercise, magnesium and immune function. Magnes Res. 2008 Jun;21(2):92-6.
52.Li XM. Complementary and alternative medicine in pediatric allergic disorders. CurrOpin Allergy ClinImmunol. 2009 Apr;9(2):161-7.
53.Litonjua AA. Childhood asthma may be a consequence of vitamin D deficiency. CurrOpin Allergy ClinImmunol 2009;9:202–207.
54.Mainardi T, Kapoor S, Bielory L. Complementary and alternative medicine: herbs, phytochemicals and vitamins and their immunologic effects. J Allergy ClinImmunol. 2009 Feb;123(2):283-94; quiz 295-6.
55.Metcalfe A, Williams J, McChesney J, et al. Use of complementary and alternative medicine by those with a chronic disease and the general population—results of a national population based survey. BMC Complement Altern Med. 2010;10:58.
56.Miyake Y, Sasaki S, Tanaka K, et al; Osaka Maternal and Child Health Study Group. Fish and fat intake and prevalence of allergic rhinitis in Japanese females: the Osaka Maternal and Child Health Study. J Am CollNutr. 2007 Jun;26(3):279-87.
57.Moneret-Vautrin DA, Morisset M. Adult food allergy. Curr Allergy Asthma Rep . 2005 Jan;5(1):80–5.
58.Morita H, He F, Kawase M, Kubota A, et al.Preliminary human study for possible alteration of serum immunoglobulin E production in perennial allergic rhinitis with fermented milk prepared with Lactobacillus gasseriTMC0356. MicrobiolImmunol. 2006;50(9):701-6.
59.Nagata Y, Yoshida M, Kitazawa H, Araki E, Gomyo T. Improvements in seasonal allergic disease with Lactobacillus plantarum No. 14. BiosciBiotechnolBiochem. 2010;74(9):1869-77.
60.O’Keefe SJ et al. Effect of fiber supplementation on the microbiota in critically ill patients. World J GastrointestPathophysiol. 2011 Dec 15;2(6):138-45.
61.Odamaki T et al. Influence of BifidobacteriumlongumBB536 intake on faecalmicrobiota in individuals with Japanese cedar pollinosis during the pollen season. J Med Microbiol. 2007 Oct;56(Pt 10):1301-8.
62.Ozdemir O. Various effects of different probiotic strains in allergic disorders: an update from laboratory and clinical data. ClinExpImmunol. 2010 Jun;160(3):295-304.
63.Pan SJ, Kuo CH, Lam KP, et al.Probiotics and allergy in children--an update review. Pediatr Allergy Immunol. 2010 Jun;21(4 Pt 2):e659-66.
64.Pawankar R, Canonica G, Holgate S, Lockey R. (eds). World Health Organization (WAO) White Book on Allergy. 2011.
65.Penders J, Stobberingh EE, van den Brandt PA, Thijs C. The role of the intestinal microbiota in the development of atopic disorders. Allergy. 2007 Nov;62(11):1223-36.
66.Randomized trial: maternal vitamin D supplementation to prevent childhood asthma (VDAART). ClinicalTrials.gov: NCT00920621.
67.Rogerio AP, Dora CL, Andrade EL, et al. Anti-inflammatory effect of quercetin-loaded microemulsion in the airways allergic inflammatory model in mice. Pharmacol Res. 2010 Apr;61(4):288-97.
68.Scarfone RJ, LoiselleJM, Joffe MD, et al. A randomized trial of magnesium in the emergency department treatment of children with asthma. Ann Emerg Med. 2000;36(6):572–8.
69.Shahar, E., Hassoun, G., and Pollack, S. (2004). Effect of vitamin E supplementation on the regular treatment of seasonal allergic rhinitis. Ann. Allergy Asthma Immunol. 92, 654–658.
70.Sharief S, Jariwala S, Kumar J, Muntner P, Melamed ML. Vitamin D levels and food and environmental allergies in the United States: results from the National Health and Nutrition Examination Survey 2005–2006. J Allergy ClinImmunol 2011;127:1195–1202.
71.Shishehbor F, Behroo L, GhafouriyanBroujerdnia M, Namjoyan F, Latifi SM. Quercetin effectively quells peanut-induced anaphylactic reactions in the peanut sensitized rats. Iran J Allergy Asthma Immunol. 2010 Mar;9(1):27-34.
72.Soutar A, Seaton A, et al. Bronchial reactivity and dietary antioxidants. Thorax . 1997 Feb;52(2):166–70.
73.Sudo N, Yu XN, Aiba Y, et al. An oral introduction of intestinal bacteria prevents the development of a long-term Th2-skewed immunological memory induced by neonatal antibiotic treatment in mice. Clinical and Experimental Allergy. 2002;32(7):1112–1116
74.Takahashi N et al. Oral administration of an immunostimulatory DNA sequence from Bifidobacteriumlongum improves Th1/Th2 balance in a murine model. BiosciBiotechnolBiochem. 2006 Aug;70(8):2013-7.
75.Thorp WA, Goldner W, Meza J, Poole JA. Reduced vitamin D levels in adult subjects with chronic urticaria. J Allergy ClinImmunol 2010;126:413.
76.Wallace DV, Dykewicz MS, Bernstein DI, et al. The diagnosis and management of rhinitis: An updated practice parameters. J Allergy ClinImmunol 2008; 122: S1-S84
77.Weiss ST, Litonjua AA. Childhood asthma is a fat-soluble vitamin deficiency disease. ClinExp Allergy 2008;38:385–387.
78.Xiao JZ, Kondo S, Yanagisawa N, et al. Probiotics in the treatment of Japanese cedar pollinosis: a double-blind placebo-controlled trial. ClinExp Allergy. 2006 Nov;36(11):1425-35.
79.Yu LC. Intestinal epithelial barrier dysfunction in food hypersensitivity. J Allergy (Cairo). 2012;2012:596081.
80.Yuksel H, Dinc G, Sakar A, et al. Prevalence and comorbidity of allergic eczema, rhinitis, and asthma in a city in western Turkey. J InvestigAllergolClinImmunol. 2008;18(1):31-5.
81.Zheng K, Adjei A, Shinjo M, et al. Effect of dietary vitamin E supplementation on murine nasal allergy. Am. J. Med. Sci. 1999. 318, 49–54.
82.Zingg JM. Vitamin E and mast cells. VitamHorm 2007;76:393-418.
83.Akbar S. Andrographispaniculata: a review of pharmacological activities and clinical effects. Altern Med Rev. 2011;16(1):66-77.
84.Akramiene D, Kondrotas A, Didziapetriene J, Kevelaitis E. Effects of beta-glucans on the immune system. Medicina. 2007;43(8):597-606.
85.AMR. Astragalusmembranaceus.Monograph.Altern Med Rev. 2003;8(1):72-77.
86.Anderson R. The Immunostimulatory, Antiinflammatory and Anti-Allergic Properties of Ascorbate. [In eng] AdvNutr Res. 1984 6(19-45.
87.Barlow PG, Svoboda P, Mackellar A, et al. Antiviral Activity and Increased Host Defense against Influenza Infection Elicited by the Human Cathelicidin Ll-37. [In eng] PLoS One. 2011 6(10): e25333.
88.Baron M. A patented strain of Bacillus coagulans increased immune response to viral challenge. Postgrad Med. 2009;121(2):114-118.
89.Barrett B, Harahan B, Brown D, Zhang Z, Brown R. Sufficiently important difference for common cold: severity reduction. Ann Fam Med. 2007;5(3):216-223.
90.Beard JA, Bearden A, Striker R. Vitamin D and the anti-viral state. J ClinVirol. 2011;50(3):194-200.
91.Berggren A, LazouAhren I, Larsson N, Onning G. Randomised, double-blind and placebo-controlled study using new probiotic lactobacilli for strengthening the body immune defence against viral infections. Eur J Nutr. 2011;50(3):203-210.
92.Berlutti F, Pantanella F, Natalizi T, et al. Antiviral Properties of Lactoferrin--a Natural Immunity Molecule. [In eng] Molecules. 2011 16(8): 6992-7018.
93.Berry DJ, Hesketh K, Power C, Hypponen E. Vitamin D status has a linear association with seasonal infections and lung function in British adults. Br J Nutr. 2011;106(9):1433-40.
94.Cannell JJ, Hollis BW. Use of vitamin D in clinical practice.Altern Med Rev. 2008;13(1):6-20.
95.Caruso TJ, Gwaltney JM, Jr. Treatment of the common cold with echinacea: a structured review. Clin Infect Dis. 2005;40(6):807-810.
96.CDC. Common Cold and Runny Nose. 5/1/2012a. Available at: http://www.cdc.gov/getsmart/antibiotic-use/URI/co... Accessed 8/24/2012.
97.Connor S. A cure for the common cold may finally be achieved as a result of a remarkable discovery in a Cambridge laboratory. 11/2/2010. Available at: http://www.independent.co.uk/news/science/a-cure-... Accessed 8/30/2012.
98.de Vrese M, Schrezenmeir J. Probiotics, prebiotics, and synbiotics. AdvBiochemEngBiotechnol. 2008;111:1-66.
99.Giese S, Sabell GR, Coussons-Read M. Impact of ingestion of rice bran and shitake mushroom extract on lymphocyte function and cytokine production in healthy rats. Journal of dietary supplements.2008;5(1):47-61.
100.Gilliland SE, Morelli L, Reid G. Health and Nutritional Properties of Probiotics in Food Including Powder Milk With Live Lactic Acid Bacteria. Rome, Italy: Food and Agriculture Organization of the United Nations World Health Organization; 2001. Available at: ftp://ftp.fao.org/es/esn/food/probio_report_en.pd... Accessed July 19, 2012
101.Grant WB, Goldstein M, Mascitelli L. Ample evidence exists from human studies that vitamin D reduces the risk of selected bacterial and viral infections. ExpBiol Med. 2010;235(12):1395-1396.
102.Hayden G. (2011) Chapter 371: The Common Cold (pg. 1434). In: Kliegman R. (Ed.), Nelson Textbook of Pediatrics (19th ed.) Saunders, An Imprint of Elsevier.
103.Heimer KA, Hart AM, Martin LG, Rubio-Wallace S. Examining the evidence for the use of vitamin C in the prophylaxis and treatment of the common cold. J Am Acad Nurse Pract. 2009;21(5):295-300.
104.Hemila H. The effect of vitamin C on the common cold: J Pharm Pract. 2011 Apr;24(2):241-2.
105.Jariwalla RJ, and Harakeh S. Antiviral and Immunomodulatory Activities of Ascorbic Acid. [In eng] SubcellBiochem. 1996 25(213-31.
106.Khalid U, Saleem T, Shah S. Therapeutic and prophylactic use of vitamin C for the common cold: J Pak Med Assoc. 2011 Dec;61(12):1252.
107.Krawitz C, Mraheil MA, Stein M, et al. Inhibitory activity of a standardized elderberry liquid extract against clinically-relevant human respiratory bacterial pathogens and influenza A and B viruses. BMC Complement Altern Med. 2011;11:16.
108.Leyer GJ, Li S, Mubasher ME, Reifer C, Ouwehand AC. Probiotic Effects on Cold and Influenza-Like Symptom Incidence and Duration in Children. Pediatrics. August 2009 2009;124(2):e172-e179.
109.Lissiman E, Bhasale AL, Cohen M. Garlic for the common cold. Cochrane Database Syst Rev. 2012;14(3).
110.Lonnerdal B. Nutritional roles of lactoferrin.CurrOpinClinNutrMetab Care. 2009;12(3):293-297.
111.MacDonald TT, Bell I. Probiotics and the immune response to vaccines. ProcNutr Soc. 2010;69(3):442-446.
112.Maggini S, Beveridge S, and Suter M. A combination of high-dose vitamin C plus zinc for the common cold. J Int Med Res. 2012;40(1):28-42.
113.Martineau AR, Jolliffe DA, Hooper RL, et al. Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data.
114.Nahas R, Balla A. Complementary and alternative medicine for prevention and treatment of the common cold. Can Fam Physician. 2011;57(1):31-36.
115.NIH (National Institutes of Health) MedlinePlus: Common Cold. Last updated July 27, 2012. Accessed July 30, 2012a at: http://www.nlm.nih.gov/medlineplus/ency/article/0...
116.Orsi N. The antimicrobial activity of lactoferrin: current status and perspectives. Biometals. 2004;17(3):189-196.
117.Ozgen M, Scheerens JC, Reese RN, Miller RA. Total phenolic, anthocyanin contents and antioxidant capacity of selected elderberry (Sambucuscanadensis L.) accessions.Pharmacogn Mag. 2010;6(23):198-203.
118.Pae M, Meydani SN, Wu D. The role of nutrition in enhancing immunity in aging. Aging Dis. 2012;3(1):91-129.
119.Pence BD, Hester SN, Donovan SM, Woods JA. Dietary whole glucan particles do not affect antibody or cell-mediated immune responses to influenza virus vaccination in mice. Immunol Invest. 2012;41(3):275-289.
120.Ross SM. A standardized Echinacea extract demonstrates efficacy in the prevention and treatment of colds in athletes. Holist NursPract. 2010;24(2):107-109.
121.Sandstead HH, Prasad AS. Zinc intake and resistance to H1N1 influenza: Am J Public Health. 2010 Jun;100(6):970-1. Epub 2010 Apr 15.
122.Simon HB. On call. I do my best to exercise every day, either walking two miles in good weather or riding my exercise bike for 30 minutes on wet or cold days. Should I keep going when I catch a cold, or would I be better off resting? HarvMens Health Watch. 2012;16(7):8.
123.Singh M, Das RR. Zinc for the common cold. Cochrane Database Syst Rev. 2011;16(2):cd001364.
124.Teodorescu MC, Teodorescu M. Tired and sick. Sleep. 2012;35(1):15-16.
125.Tierra M. Echinacea: an effective alternative to antibiotics. J Herb Pharmacother. 2007;7(2):79-89.
126.Toselli F, Matthias A, Gillam EM. Echinacea metabolism and drug interactions: the case for standardization of a complementary medicine. Life Sci. 2009;85(3-4):97-106.
127.Vouloumanou EK, Makris GC, Karageorgopoulos DE, Falagas ME. Probiotics for the prevention of respiratory tract infections: a systematic review. Int J Antimicrob Agents. 2009;34(3):28.
128.Waarts BL, Aneke OJ, Smit JM, et al. Antiviral Activity of Human Lactoferrin: Inhibition of Alphavirus Interaction with Heparan Sulfate. [In eng] Virology. 2005 Mar 15; 333(2): 284-92.
129.Woelkart K, Linde K, Bauer R. Echinacea for preventing and treating the common cold. Planta Med. 2008;74(6):633-637.
130.Wolvers D, Antoine JM, Myllyluoma E, Schrezenmeir J, Szajewska H, Rijkers GT. Guidance for substantiating the evidence for beneficial effects of probiotics: prevention and management of infections by probiotics. J Nutr. 2010;140(3):27.
131.Worrall G. Common cold. Can Fam Physician. 2011;57(11):1289-1290.
132.Zakay-Rones Z, Thom E, Wollan T, Wadstein J. Randomized study of the efficacy and safety of oral elderberry extract in the treatment of influenza A and B virus infections. J Int Med Res. 2004;32(2):132-40.
133.A.D.A.M. Medical Encyclopedia. Copyright © 2013. Attention deficit hyperactivity disorder. ADD; ADHD; Childhood hyperkinesis. PubMed Health web page. Available at: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH00025... Accessed 12/4/2013.
134.Abramovitch A, Goldzweig G, Schweiger A. Correlates of Physical Activity with Intrusive Thoughts, Worry and Impulsivity in Adults with Attention Deficit/Hyperactivity Disorder: A Cross-sectional Pilot Study. The Israel journal of psychiatry and related sciences. 2013;50(1):47-53.
135.Akhondzadeh S, Mohammadi MR, Khademi M. Zinc sulfate as an adjunct to methylphenidate for the treatment of ADHD in children: a double blind and randomized trial [ISRCTN64132371]. BMC Psychiatry. 2004 Apr 08;4(1):9.
136.Arnold LE, Amato A, Bozzolo H, Hollway J, Cook A, Ramadan Y, Crowl L, Zhang D, Thompson S, Testa G, Kliewer V, Wigal T, McBurnett K, Manos M. Acetyl-L-carnitine (ALC) in attention-deficit/hyperactivity disorder: a multi-site, placebo-controlled pilot trial. J Child Adolesc Psychopharmacol. 2007 Dec;17(6):791-802.
137.Arnold LE, Hurt E, Lofthouse N. Attention-Deficit/Hyperactivity Disorder: Dietary and Nutritional Treatments. Child Adolesc Psychiatric N Am. 2013;22(3):381-402.
138.Berwid OG, Halperin JM. Emerging support for a role of exercise in attention-deficit/hyperactivity disorder intervention planning. Current psychiatry reports. Oct 2012;14(5):543-551.
139.Bloch MH, Qawasmi A. Omega-3 fatty acid supplementation for the treatment of children with attention-deficit/hyperactivity disorder symptomatology: systematic review and meta-analysis. Journal of the American Academy of Child and Adolescent Psychiatry. Oct 2011;50(10):991-1000.
140.Carlson SJ, Fallon EM, Kalish BT, Gura KM, Puder M. The role of the omega-3 fatty acid DHA in the human life cycle. JPEN. Journal of parenteral and enteral nutrition. Jan 2013;37(1):15-22.
141.Eme R. ADHD: an integration with pediatric traumatic brain injury. Expert Rev Neurother. 2012 Apr;12(4):475-83.
142.Ghanizadeh A. A systematic review of magnesium therapy for treating attention deficit hyperactivity disorder. Archives of Iranian medicine. Jul 2013;16(7):412-417.
143.Gow RV, Sumich A, Vallee-Tourangeau F, Crawford MA, Ghebremeskel K, Bueno AA, . . . Rubia K. Omega-3 fatty acids are related to abnormal emotion processing in adolescent boys with attention deficit hyperactivity disorder. Prostaglandins, leukotrienes, and essential fatty acids. Jun 2013;88(6):419-429.
144.Gow RV, Vallee-Tourangeau F, Crawford MA, Taylor E, Ghebremeskel K, Bueno AA, . . . Rubia K. Omega-3 fatty acids are inversely related to callous and unemotional traits in adolescent boys with attention deficit hyperactivity disorder. Prostaglandins, leukotrienes, and essential fatty acids. Jun 2013;88(6):411-418.
145.Hariprasad VR, Arasappa R, Varambally S, Srinath S, Gangadhar BN. Feasibility and efficacy of yoga as an add-on intervention in attention deficit-hyperactivity disorder: An exploratory study. Indian journal of psychiatry. Jul 2013;55(Suppl 3):S379-384.
146.Hirayama S, Terasawa K, Rabeler R, Hirayama T, Inoue T, Tatsumi Y, . . . Jager R. The effect of phosphatidylserine administration on memory and symptoms of attention-deficit hyperactivity disorder: a randomised, double-blind, placebo-controlled clinical trial. Journal of human nutrition and dietetics : the official journal of the British Dietetic Association. Mar 17 2013.
147.Johnson M, Mansson JE, Ostlund S, Fransson G, Areskoug B, Hjalmarsson K, . . . Gillberg C. Fatty acids in ADHD: plasma profiles in a placebo-controlled study of Omega 3/6 fatty acids in children and adolescents. Attention deficit and hyperactivity disorders. Dec 2012;4(4):199-204.
148.Johnson M, Ostlund S, Fransson G, Kadesjö B, Gillberg C. Omega-3/omega-6 fatty acids for attention deficit hyperactivity disorder: a randomized placebo-controlled trial in children and adolescents. J Atten Disord. 2009;12(5):394–401
149.Konofal E, Lecendreux M, Arnulf I, Mouren MC. Iron deficiency in children with attention-deficit/hyperactivity disorder. Arch Pediatr Adolesc Med. 2004 Dec;158(12):1113-5.
150.Konofal E, Lecendreux M, Deron J, Marchand M, Cortese S, Zaim M, . . . Arnulf I. Effects of iron supplementation on attention deficit hyperactivity disorder in children. Pediatric neurology. Jan 2008;38(1):20-26.
151.Kozielec T, Starobrat-Hermelin B. Assessment of magnesium levels in children with attention deficit hyperactivity disorder (ADHD). Magnesium research : official organ of the International Society for the Development of Research on Magnesium. Jun 1997;10(2):143-148.
152.Manor I, Magen A, Keidar D, Rosen S, Tasker H, Cohen T, . . . Weizman A. The effect of phosphatidylserine containing Omega3 fatty-acids on attention-deficit hyperactivity disorder symptoms in children: a double-blind placebo-controlled trial, followed by an open-label extension. European psychiatry : the journal of the Association of European Psychiatrists. Jul 2012;27(5):335-342.
153.Montgomery P, Burton JR, Sewell RP, Spreckelsen TF, Richardson AJ. Low blood long chain omega-3 fatty acids in UK children are associated with poor cognitive performance and behavior: a cross-sectional analysis from the DOLAB study. PloS one. 2013;8(6):e66697.
154.Mousain-Bosc M, Roche M, Polge A, Pradal-Prat D, Rapin J, Bali JP. Improvement of neurobehavioral disorders in children supplemented with magnesium-vitamin B6. I. Attention deficit hyperactivity disorders. Magnesium research : official organ of the International Society for the Development of Research on Magnesium. Mar 2006;19(1):46-52.
155.Mousain-Bosc M, Roche M, Rapin J, Bali JP. Magnesium VitB6 intake reduces central nervous system hyperexcitability in children. J Am Coll Nutr. 2004 Oct;23(5):545S-8S.
156.Owens JA. The ADHD and sleep conundrum: a review. Journal of developmental and behavioral pediatrics : JDBP. Aug 2005;26(4):312-322.
157.Patterson E, Wall R, Fitzgerald GF, Ross RP, Stanton C. Health implications of high dietary omega-6 polyunsaturated Fatty acids. Journal of nutrition and metabolism. 2012;2012:539426.
158.Pellow J, Solomon EM, Barnard CN. Complementary and alternative medical therapies for children with attention-deficit/hyperactivity disorder (ADHD). Altern Med Rev. 2011 Dec;16(4):323-37.
159.Rucklidge JJ, Johnstone J, Kaplan BJ. Nutrient supplementation approaches in the treatment of ADHD. Expert review of neurotherapeutics. Apr 2009;9(4):461-476.
160.Sever Y, Ashkenazi A, Tyano S, Weizman A. Iron treatment in children with attention deficit hyperactivity disorder. A preliminary report. Neuropsychobiology. 1997;35(4):178-180.
161.Starobrat-Hermelin B, Kozielec T. The effects of magnesium physiological supplementation on hyperactivity in children with ADHD. Positive response to magnesium oral loading test. Magnes Res. 1997 Jun;10(2):149-56.
162.Stein MA, Weiss M, Hlavaty L. ADHD treatments, sleep, and sleep problems: complex associations. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. Jul 2012;9(3):509-517.
163.Torrioli MG, Vernacotola S, Peruzzi L, Tabolacci E, Mila M, Militerni R, . . . Neri G. A double-blind, parallel, multicenter comparison of L-acetylcarnitine with placebo on the attention deficit hyperactivity disorder in fragile X syndrome boys. American journal of medical genetics. Part A. Apr 1 2008;146(7):803-812.