How To Prevent or Improve Conditions of Prostate Cancer

How To Prevent or Improve Conditions of Prostate Cancer

Prostate related conditions and prostate cancer affect a large group of men every year. New data reveals that many men have underlying prostate cancer without even knowing it. Some types of prostate cancer are usually slow-growing and it can be years before symptoms become a problem. Evidence based studies provide a number of effective methods to slow prostate cancer progression, improve post surgery conditions, as well as offering preventive solutions. More specifically, advancements in Integrative and complementary medicine research provide promising results in protecting against prostate cancer, inhibiting its development or progression, reducing treatment side effects, enhancing treatment outcomes, and recovering from post surgical conditions.

What is the prostate gland and prostate cancer?

Prostate gland is a part of the male reproductive system. It produces and stores the fluid part of the semen and plays a role in urine control. Prostate gland is about 3 cm in diameters and located in the pelvis, under the bladder. The prostate requires androgen (male hormone) known as testosterone to function properly. Because of its location, prostate conditions are usually accompanied by urinating and sexual performance problems.

While majority of the prostate tumors grow slowly, some may grow rapidly. Prostate cancer cells may spread to the near organs, such as bladder, bones, and lymph nodes.

Most prostate cancers are classified as glandular cancers (adenocarcinomas) and results from mutation of the normal semen producing cells. Initially these small group of cells remain restricted within the normal cells. This condition is known as prostatic intraepithelial neoplasia (PIN). Nearly 50% of all men over the age of 50 may have PIN. While there is not enough evidence to prove PIN initializing prostate cancer, close associations has been established. Usually low-grade PIN is not a cause for concern, however it make sense to consider preventative steps.

Risk factors of prostate cancer include aging, obesity, certain diseases, family history, race, a diet high in saturated fat, processed meat, high fat dairy products, alcohol, vitamin D deficiency, exposure to certain toxins and medications, history of STD infection, and Inflammation (prostatitis).

PSA screening, PCA3 test which is examining the urine for the PCA3 gene only found in prostate cancer cells, ultrasound, MRI and biopsy are the diagnostic steps taken to gather more information to evaluate the health of prostate and the urinary tract.

Some prostate cancers may not require a treatment specially the low grade, slow growing forms in elderly men whom may have other health conditions, instead a watchful waiting approach is taken which may include palliative or active surveillance strategies.

Prostate cancer treatment guidelines for specific clinical situations requires a good estimation of a person's long-term life expectancy and the stage of the disease. Treatment options include; prostatectomy method though which the gland is surgically removed - Robotic keyhole new method of surgery is more precise with less recovery time- variation of radiation therapy, chemotherapy, cryosurgery, hormonal therapy, or some combination.

How to reduce the risk of prostate cancer?

Try to stay away from processed food, especially processed meat like sausage, and hot dogs. High temperature cooking techniques such as broiling and grilling cause formation of HCA compounds (heterocyclic amines) which have been linked to a variety of cancers. Consider lean poultry, wild fish, legumes, nuts, antioxidant reach foods or super foods instead.

According to researches published in journal of nutrition, consuming a large number of dairies especially high fat dairy products such as whole milk, full fat cheese, butter, ice cream, cream cheese, and other similar products contribute to the progression of prostate cancer cells. Try to limit dairy consumption, or at least pick the low fat or non dairy options. Avoid saturated fats, replace them with healthy unsaturated fats like avocado, fish, olive, etc.

Data from more than 10,000 men participating in the Prostate Cancer Prevention trial, indicated that heavy alcohol drinkers were twice as likely to be diagnosed with advanced prostate cancer. Heavy drinkers are defined as those who consume more than three drinks a day or more than 20 drinks a week. Non alcoholic beers and wines, and alcohol free versions of the favorite cocktails are a great way of reducing alcohol consumption.

Limit exposure to environmental toxins and pesticides. For instance high level cadmium is caused by cigarette smoking and some occupational exposures such as welders, metal workers, or those who make cadmium products such as batteries or plastics. Environmental toxic estrogen like bisphenol A is found in polycarbonate plastic; Bisphenol A can also be found in farm-raised fish.

Be proactive, prevention and inhibition of prostate cancer can include a number of lifestyle actions. Various complementary medicine options, and nutrients have been shown to be effective in removing cancer causing toxins, improving the immune function, protecting against prostate cancer and inhibiting its development or progression.

Which kind of complementary medicine can help?

Recent data from research on wide range of phyto nutrients, nutrition, antioxidants, minerals, vitamins, homeopathic medicine, and acupuncture is indicative of their beneficial and complementary role in preventing prostate conditions and improving state of health. These methods are safely and effectively being employed along with the usual treatment options and /or used to help prevent or attenuate prostate cancer development.

How complementary medicine may help to prevent prostate cancer?

During the past two decades, there has been an increase in the use of complementary medicine for neoplastic diseases and that has led to more research. More and more data is confirming the benefits of using complementary medicine.

For instance, nowadays it is more evident that nutrition, preventing deficiencies, keeping hormone balance are the first defence against prostate cancer.

Published scientific studies suggest a range of nutrients that have been found to help reduce risk of prostate cancer. These nutrients act via different mechanisms to inhibit the development and progression of prostate cancer and/or induce cancer cell apoptosis (cell destruction).

Results from controlled clinical trials have shown effectiveness of using particular nutrients in men who failed initial treatment for prostate cancer.

More data from European countries has shown that homeopathic treatment has been more frequently used in conjunction with and/or prior to the usual treatments. 30% of all the referrals to the homeopathic hospital in the Uk come from oncologists. While homeopathy has been used as an effective palliative and supportive treatment, new evidence suggests that certain homeopathic remedies may provide anticancer properties and could be beneficial in symptom management, in reducing treatment related side effects, as well as in helping to strength the immune system and improving general well being.

Aging men, now have access to more possibilities and opportunity to reduce their risk for prostate cancer, as well as other degenerative diseases.

Which nutrients can help to reduce risk of prostate cancer?

Phytochemical known as DIM derived from cruciferous vegetables (such as broccoli, kale, cauliflower, and Brussels sprouts) have shown promising results in inhibiting prostate cancer in experimental models.

Dim is shown to inhibit the phosphorus-transferring enzyme Akt, as well as the master DNA-transcription regulator nuclear factor-kappaB (NF-kB); also to block the communication or signaling between them. Through these mechanisms DIM stops cell growth and induces apoptosis (cell death) in prostate cancer cells while it does not impact the normal prostate epithelial cells. The ability of DIM to target abnormal epigenetic changes along with its detoxifying power for carcinogens, make it an effective and beneficial factor to be employed at any stage of the prostate condition.

Several clinical trials have been conducted to evaluate the tolerability and safety of DIM in men with or at high risk for prostate cancer. In a pre-surgical protocol, short-term administration of DIM (100 or 200 mg twice daily) was well-tolerated in 45 patients with prostate cancer. Similarly, daily oral administration of 900 mg DIM for three months was well-tolerated by men with prostatic intraepithelial neoplasia (PIN). Taken in supplement form, DIM by itself cannot be absorbed properly by the human body. Microencapsulated DIM complex has shown to provide significant oral bioavailability. All published clinical trials examining DIM have only used microencapsulated DIM complex.

Curcumin has been widely studied for its anticancer properties. Curcumin is a multifunctional compound which induces the cancerous cell apoptosis (cell death), impacts the spread of cancer cells, and regulates inflammatory responses through the master regulator nuclear factor-kappaB (NF-kB) which is a protein complex that controls the DNA transcription. Natural molecules that inhibit NF-kB can limit inflammation.

Prostate cancer cells are often dependent on the androgen hormones to grow. Curcumin is shown to reduce the expression androgen receptors and androgen receptor-related cofactors in the prostate. This interferes with what the cancer cells are depending on to grow.

Both in vitro and in vivostudies demonstrate that curcumin inhibits prostate cancer promotion by blocking metastases of cancer cells in the prostate, and by regulating those necessary enzymes required to invade the tissues.

In certain human prostate cancer cell lines, curcumin could completely inhibit a type of phosphorus-transferring enzyme known as Akt (or protein kinase B orPKB), which is suggested to be one of the mechanism through curcumin can limit the cancer cells growth. In vivo curcumin has been also shown to inhibit angiogenesis in prostate cancer cells.

Curcumin's effectiveness is greatly depends on its absorption and sustainability in plasma. Only bioactive types of curcumin would be actually absorbed and stay in the human body at the level that could provide therapeutic benefits. Regular curcumin extracts even at the 95% extraction would still have poor bioavailability.

Green tea components provide many biological effects, including antitumor and cancer preventive activities. In the search for anticancer agents for prostate cancer the inhibitory effects of green tea components were tested on the prostate cancer cell lines. (EGCG) proved to be the most potent catechin at inhibiting cell growth. EGCG induced apoptotic cell death which was observed by changes in nuclear and DNA.

In an in vivo study of human prostate cancer cells, green tea polyphenols and its major constituent, epigallocatechin-3-gallate (EGCG) were found to be able to re-activate epigenetically silenced genes in cancer cells that were supposed to control cells from becoming invasive and migrant.

Green tea catechins (GTCs) are proven to be effective in inhibiting cancer growth in several experimental models. Recent studies showed that 30% of men with high-grade prostate intraepithelial neoplasia (HG-PIN) would develop prostate cancer within 1 year after repeated biopsy. In a double blind control study 60 volunteers with HG-PIN where enrolled; After 1 year , only 3% (1 Case) of those who took 600 mg daily of the green tea extract developed a tumor, while in the placebo group 30% ( 9 Cases) were diagnosed with tumor. The International Prostate Symptom Score and quality of life scores of GTCs-treated men with coexistent benign prostate hyperplasia improved, reaching statistical significance in the case of International Prostate Symptom Scores. No significant side effects or adverse effects were documented. Concluding Green tea catechins to be safe and effective for treating pre-malignant cases before progression to prostate cancer.

As a secondary observation, administration of GTCs showed to reduce lower urinary tract symptoms, suggesting that these compounds might also be of help for treating the symptoms of benign prostate hyperplasia.

Administration 1,300 milligrams of green tea polyphenols, mostly EGCG as an adjuvant to prostate cancer patients prior to surgery showed to significantly lower the PSA and other tumor promoters such as vascular endothelial growth factor. Overall results from the clinical trials so far, suggest that the therapeutic window for Green tea catechins intervention is narrow and possibly corresponds to early signs of prostate tissue transformation such as HG-PIN; and inadequate dosage and/or short intervention periods may compromise the therapeutic effect.

In vitro studies suggests that pomegranate extract's effects against prostate cancer cells is via inducing beneficial gene expressions to produce higher proteins which promote cell death; while inhibiting pro-inflammatory, DNA-related protein nuclear factor kappa B (NF-kB) and production of cancer-stimulating androgen receptors in prostate cells. Further lab research has shown that the effect of pomegranate extract against prostate cancer cells is dose dependent.

Later human studies found that administration of pomegranate extract to the patients with biochemical recurrence (BCR) following local therapy for prostate cancer, delayed their PSA doubling time suggesting that could be used safely for adjuvant cancer therapy.

Resveratrol belongs to a group of phyto-chemicals known as Phytoalexins produced in plants as a defense mechanism.

Resveratrol has shown to inhibit prostate cancer at multiple stages of development. In a study that examined the effect of various polyphenols on different types of prostate cancer cells, scientists concluded that resveratrol was the most potent against advanced prostate cancer cells. Resveratrol is shown to be able to modulate estrogen and testosterone activities at both the cellular receptor and genetic levels. Resveratrol modulates growth factors, protects DNA, prohibits cancer-causing chemicals and radiation, works against free radicals and inflammation, and enhances expression of anticancer genes.

Resveratrol lowers the elevated PSA. In a clinical study four days of taking resveratrol resulted in 80% PSA reduction in prostate cancer.

Resveratrol is shown to be able to work inside cancer cells and activate or deactivate genes to limit cancer growth. It activates tumor suppressor genes, other genes that destroy cancer cells, and genes that control the cell cycle; while, suppresses those genes used by cancer cells to communicate with one another; especially since resveratrol exerts its effects without toxicity.

Resveretrol is quite rapidly metabolized by the liver and that has an impact on its bioavailability; however, if sustained resveratrol levels can be achieved in the gastrointestinal tract, there is evidence of a powerful antitumoral effect. Resveretrols activity is seen to be enhanced when taken with Curcumin and quercetin or other member of phytoalexins known as Pterostilbene. General suggested dose for resveratrol is between is 20 to 250 mg daily.

Modified citrus pectin is the bio available form pectin fiber from the citrus plants. Modified citrus pectin is water soluble and can attach to certain molecules.

Modified citrus pectin (MCP) is an effective inhibitor of galectin-3 (Gal-3), which is correlated with tumor progression, proliferation, angiogenesis, and apoptosis. A small study indicated that modified citrus pectin can increase the PSA doubling time in men with prostate cancer who did not respond to localized treatment.

Clinical trials suggest that MCP significantly reduced the invasive and migratory potential of prostate cancer cells. Modified citrus pectin (MCP) is an effective inhibitor of galectin-3 (Gal-3), which is correlated with tumor progression, proliferation, angiogenesis, and apoptosis.

Radio-resistance cancer cells are major cause of decreasing the efficiency of radiotherapy for prostate cancer, however clinical studies show using MCP in conjunction with radiotherapy enhances the treatment outcome suggesting that MCP is a radiosensitizer for prostate cancer cells and help to reduce clinical IR dose.

Modified citrus pectin supplements should be taken without food and the suggested dosage is 5 to 15 grams per day.

Vitamin D impacts at least 200 human genes that are involved in regulating cell proliferation, development, and apoptosis. Numerous studies have shown that vitamin D status has a direct effect on cancer risk. In recent years, a multitude of studies have shown cancer risk reductions of 50% and greater based on higher vitamin D status. Men who have higher levels of vitamin D, have a lower risk of prostate cancer. Blood testing determines the appropriate dosages, which could range from 2,000 IU to 10,000 IU daily for prevention.

Low Coenzyme Q10 (CoQ10 or Q10) is often seen in patients with a variety of cancer types. Several published animal and human studies have demonstrated that supplementing with CoQ10’s provide great effects against some cancers.

Based on the clinical studies on prostate cancer patients, lycopene supplementation helps to decrease the growth of prostate cancer. Healthy men with the highest blood lycopene levels are shown to have a 60% reduced risk of developing prostate cancer.

Scientific research suggests that lycopene works by reducing oxidative stress in prostate tissue; lowering inflammation; preventing DNA damage; modulating expression of androgen receptors; and it may block cancer cells growth by interfering with cancer cell communication. Lycopene also may help to slow down angiogenesis (formation of new blood vessel) around cancer cells.

Body only requires a tiny amount of selenium, however, its blood levels decrease with age which contributes to deficiencies. Lower levels of selenium in the blood can correspond to an increased risk of an enlarged prostate, the condition known as benign prostatic hyperplasia (BPH). Lower selenium levels were also found to enhance risk of prostate cancer by 4-5 times. Luckily, taking selenium supplement has been shown to reduce risk of prostate cancer up to 63%. This appears to be related to an antiproliferative effect, by modulating cell-cycle regulators. More research suggests that selenium's efficiency would be higher when combined with gamma-tocopherol, an isomer of vitamin E.

Total zinc level in the prostate is much higher than in other soft tissues in the body, and it is found to be significantly lower in those with prostate cancer have been shown to have exceedingly low levels of zinc in the prostate. Apparently prostate cancer cells lose their ability to accumulate zinc. Although zinc supplementation helps to reduce the risk of prostate cancer, it is shown to be most helpful to reduce risk of advanced prostate cancer.

Milk thistle has been studied for its protective properties against prostate cancer, active ingredients including isosilybin, silibinin, and silymarin. Both silibinin and silymarin and are strong antioxidants and inhibit human carcinoma cell growth and DNA synthesis, and angiogenesis.

Saw palmetto (Serenoa repens or Sabal serrulata) is one of the most widely used for BPH (benign prostatic hyperplasia). Evidently saw palmetto also has biological activity in prostate cancer cells and may defend against prostate cancer. Saw palmetto extract was shown to inhibit the activity of 5-alpha-reductase, an enzyme that converts testosterone to the most potent androgen and that is involved in the pathway of prostate cancer. Saw palmetto also appears to have anti-inflammatory properties with a tendency to promote apoptosis (cell death) in prostate cancer cells. In vitro saw palmetto extract reduced the expression of cyclooxygenase-2 (COX-2). Cox 2 is form of biological booster for cancer cells to hyperproliferate.

Beta-sito-sterol is a type of plant fat (phytosterol) that has been found to block the growth of prostate cancer cells. A study on an androgen-dependent prostate cancer cells showed that beta-sitosterol decreased cancer cell growth by 24% and induce apoptosis up to 4 times.

NAC is an antioxidant and it promotes metabolism of glutathione (a potent antioxidant) . In in-vitro studies, NAC found to significantly inhibit androgen-independent prostate carcinoma cells (PC-3 cells) in a dose and time dependent manner, suggesting NAC may be of benefit in the management of prostate cancer. NAC has high potential to attenuate migration of human prostate cancer cells and to suppress the growth of primary and secondary tumors. NAC is usually available in 600 mg dose but higher dosages may be needed for adjuvant cancer therapy.

High blood levels of the omega-3 fatty acids DHA and EPA (docosahexaenoic acid and eicosapentaenoic acid) have been shown to correspond to a lower risk of developing prostate cancer. EPA down regulates inflammation and it has also been found to play a role in inhibiting uPA (urokinase-type plasminogen activator) which is believed to take part in prostate cancer invasion and metastasis. Suggested dosages are 2-4 grams of omega 3 to provide 700-1,400 mg of EPA and 500-1,000 mg of DHA, daily with food.

Cancer is caused by genetic mutations, so it makes sense to prevent such cell damage. Antioxidants compounds prevent damage to cells caused by free radicals. Free radicals are highly reactive and take electrons from other molecules in an effort to achieve molecular stability. Taking electrons from DNA molecules cause damage which partly contributes to aging as well as mutations.

Systemic inflammation has been shown to contribute to cancer and many other health conditions. Hydrogenated oils, processed food, saturated fats, dairy and simple sugars are contributors to inflammation. Complementary medicine provides verity of very effective ways to lower inflammation.

Toxins accumulate in tissues and interfere with the ability to heal. It is highly recommended to identify those toxins and eliminate them without interrupting health. Complementary medicine offers safe methods to eliminate toxins while preserving healthy tissues and cells.

Cancer treatment such as chemotherapy severely weaken the immune system. Well balanced diet and replenishing nutrients would be essential to restore immune health.

Lifestyle changes may affect the progression of early, low grade prostate cancer in men. Treatment of prostate cancer is difficult and somewhat controversial. Therefore, strategies that could enhance primary prevention are invaluable. The efficacy of each or combination of complementary medicines as an adjuvant to the regular treatment depends on variety of factors including patients overall health, the stage of the disease and the method of the treatment.


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