Bioclinic Naturals Urinary-Pro 60 Tablets

Cautions: No known interactions exist. As a diuretic, bearberry theoretically may increase serum lithium levels, but this has not been shown clinically. Berberine has been shown to lower blood glucose levels and may have an additive effect when combined with other hypoglycemic agents. Berberine has also been shown to increase levels of cyclosporin A, and combined use should be avoided. Berberine has demonstrated inhibitory activity on cytochrome enzymes CYP2D6, CYP3A4, and CYP2C9, and use of agents metabolized by these enzymes should be monitored. Echinacea has been shown to reduce the required immune inhibitory agents dosage in inflammatory conditions, and may improve the efficacy of antifungal treatments for infection with Candida sp.^16,17,18 Although direct evidence of interactions with echinacea is lacking, it is a weak inhibitor of CYP1A2 and a minor inducer of CYP3A4, and may have a slight effect on agents metabolized through these pathways.