Bioclinic Naturals EstroVantage EM 90 Veg Capsules
Bioclinic Naturals EstroVantage EM 90 Veg Capsules :
In general, estrogen can be divided into several biochemically distinct hormones: E1, E2, E3, and E-17β. In premenopausal women, estrogen is enzymatically converted to several specific estrogen metabolites of : 2-OHE1, 4-OHE1, 16α-OHE1, 2-OHE2, and 4-OHE2.
16α-OHE1 is an estrogen agonist and proliferative while 2-OHE is an estrogen antagonist and antiproliferative.3 Several natural ingredients found in EstroVantage EM contribute to this latter concept are including DIM, and indole 3 carbinol (I3C) without notable adverse events. Other ingredients in EstroVantage EM, including calcium-d-glucarate down-regulates the enzyme beta-glucoronidase activity, allowing for the excretion of estrogen before reabsorption.5
- Increase in marker IGF-1 plays a role in pathology of cancer, Lycopene adversely impacts the level of IGF-1.
- Green tea polyphenols down-regulate the proliferation of breast cancer cells in vivo and in vitro9.
- Silymarin helps to down-regulate the gene products involved in the proliferation of tumour cells (cyclin D1, EGFR, COX-2, TGF-beta, IGF-IR), invasion (MMP-9), angiogenesis, and metastasis (adhesion molecules)10.
- Curcumin mediates certain signalling cascades including the NF-κB signalling pathway11
- Sulforaphane helps to lower expression of estrogen receptor alpha (ERalpha) protein in MCF-7 cells.
|Each Capsule Contains:|
|Calcium D-Glucarate (d-Glucaric Acid Calcium Salt)||75 mg|
|Indole-3-Carbinol (3-Hydroxymethylindole)||75 mg|
|Green Tea Extract (Camellia sinensis) (leaf)(80% Catechins, 45% EGCg <1% Caffeine)||50 mg|
|Tomato Extract (Lycopersicon esculentum)(fruit) (5% Lycopene)||50 mg|
|Broccoli Powder (Brassica oleracea var. italica)(aerial) (0.36% Sulforaphane)||27.5 mg|
|Turmeric Extract (Curcuma longa) (rhizome)(95% Curcuminoids)||25 mg|
|DIM (3,3’-Diindolylmethane)||25 mg|
|Rosemary Extract (Rosmarinus officinalis) (leaf)||12.5 mg|
Non-medicinal Ingredients : Microcrystalline cellulose, vegetarian capsule (carbohydrate gum [cellulose], purified water), vegetable grade magnesium stearate (lubricant), silica.
Allergens : Contains no artificial preservatives, colours or sweeteners and no dairy, wheat or yeast. Sealed for your protection. Do not use if seal is broken. For freshness, store in a cool, dry place.
Recommended Adult Dose : 3 capsules per day taken with food or as directed by a health care practitioner. Consult a health care practitioner for use beyond 12 weeks. Keep out of reach of children.
Contraindications : Do not use if you are pregnant or breastfeeding, or if you have iron deficiency. Consult a health care practitioner prior to use if you have a liver disease or develop symptoms of liver trouble. Hypersensitivity/allergy is known to occur, in which case discontinue use. Consult a health care practitioner if you have gallstones or a bile duct obstruction, stomach ulcers or excess stomach acids, if you are taking antiplatelets or blood thinners, or if you are attempting to conceive. Keep out of reach of children.
Interactions :Do not take with blood thinners, antiplatelets, or anticoagulants.