Aor D Glucarate Plus Milk Thistle 60 Veg Capsules

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1061
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624917042726
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Description

Aor D Glucarate Milk Thistle :

Helps with the body's detox process of glucuronidation. Supports liver function and healthy cells.

Contains Milk thistle which helps to support liver function and is used for its a liver protecting benefits.

Ingredients:

Supplement Facts Per 2 Capsules:
Calcium d-Glucarate
150 mg
Milk Thistle Dry Extract (80% Silymarin)
175 mg

 

Non-medicinal ingredients: microcrystalline cellulose, silicon dioxide. Capsule: hypromellose. 

Purity: no ingredients not listed on the label have been added to the product. Contains no wheat, gluten, corn, nuts, dairy, soy, eggs, fish, shellfish, or any animal byproduct.

Suggested Dose: Take 1 capsule twice daily with food, or as directed by a qualified health care professional. Use for a minimum of 3 weeks to see beneficial effects.

Cautions: Consult a health care practitioner prior to use if you are taking other medications or antibiotics, for use beyond 28 days, or if symptoms persist or worsen. Do not use if you have a liver or eye condition, or have Sly disease. Discontinue use if a hypersensitivity develops (such as an allergy) or if symptoms of liver trouble or corneal clouding develop.

Main Indications: 
Detoxification, Liver health, Healthy Cellular growth.

Every moment of every day, every cell in the body is impacted by artificial and natural chemicals, biological metabolites, exess level of hormones such as estrogen and testosterone which pose potential cause of cancer. 

What is Glucuronidation(Phase II Detoxification)?

The body through enzymatic pathways processes xenobiotic and naturally occurring toxins. One of the most important such pathways is glucuronidation, in which UGT enzymes (uridine 5'-diphospho-glucuronosyltransferase) disables carcinogens by binding them to a molecule of glucuronic acid. This is an essential part of phase II detoxification. Via this process potential carcinogens will change to less damaging to the cells and leave the body. It also makes many such chemicals easier for the body to excrete through the urine or the bile. Glucuronidation can be undone by an enzyme known as beta glucuronidase. This enzyme frees up the original carcinogen from its glucuronic acid. Beta-glucuronidase is present in the cells and is also produced by some fecal bacteria. The activity of beta-glucuronidase increases with age.

D-Glucarate:

D-glucarate is made in small amounts by the body but found mainly in foods like oranges and cruciferous vegetables like broccoli. Interestingly enough, such foods also contain other protecting nutrients, including glucoraphanin glucosinolate (SGS), IP6, DIM and I3C.

D-Glucarate contributes to less activity of the beta-glucuronidase enzyme in tissues all over the body, including key organs like the liver, spleen, breast, lung, and prostate resulting in higher net glucuronidation activity. This boost to your body's glucuronidation capacity.

D-Glucarate & Cancer:

Cancer causes disruption in D-Glucarate levels. Impaired glucuronidation has been linked to susceptibility to many cancers and other diseases in humans and in other species. Human research suggests that there are links between toxic environments, glucuronidation, beta-glucuronidase activity, and cancer and other diseases.

Milk Thistle:

Milk thistle has been used in traditional medicine to help support general liver health and function and in conditions such as alcoholic cirrhosis, hepatitis, and fibrosis. It is known for protecting the liver and helping the liver self-regenerate after damage.

The liver has many functions, one of which is detox process which is more efficient when the liver is functioning optimally. Compromised liver function and detox process leads to toxic build-up in the body, causing illness and disease.

Silymarin’s Benefits for the Liver:

Silymarin is milk thistle’s main active ingredient, which is actually a group of flavonolignans called silybins. It acts as an antioxidant to help  protect cells, especially liver cells, from free-radical damage and lipid peroxidation. It helps with DNA synthesis in hepatocytes, the liver cells for liver tissue repair and regeneration.

Milk thistle participates in modulation of pro-inflammatory signals and markers such as NF-kB. Silymarin assists in metal-chelating including iron and arsenic. 

Silymarin benefits metabolic parameters such as cholesterol, LDL,  blood sugar , triglycerides, HbA1c , and amyloid-beta plaque.

References:

  1. Abou-Issa H, Moeschberger M, el-Masry W, Tejwani S, Curley RW Jr, Webb TE. "Relative efficacy of glucarate on the initiation and promotion phases of rat mammary carcinogenesis." Anticancer Res. 1995 May-Jun; 15(3): 805-10. Calcium-D-glucarate. Altern Med Rev. 2002 Aug;7(4):336-9.
  2. Cheng B, Gong H, Li X, Sun Y, Zhang X, Chen H, Liu X, Zheng L, Huang K. Silibinin inhibits the toxic aggregation of human islet amyloid polypeptide. Biochem Biophys Res Commun. 2012 Mar 16;419(3):495-9. Epub 2012 Feb 14. Heerdt AS, Young CW, Borgen PI. "Calcium glucarate as a chemopreventive agent in breast cancer." Isr J Med Sci. 1995 Feb-Mar; 31(2-3): 101-5. Huseini HF, Larijani B, Heshmat R, Fakhrzadeh H, Radjabipour B, Toliat T, Raza M. The efficacy of Silybum marianum (L.) Gaertn. (silymarin) in the treatment of type II diabetes: a randomized, double-blind, placebo-controlled, clinical trial. Phytother Res. 2006 Dec;20(12):1036-9.
  3. Kaur G, Athar M, Alam MS. Dietary supplementation of silymarin protects against chemically induced nephrotoxicity, inflammation and renal tumor promotion response. Invest New Drugs. 2010 Oct;28(5):703-13. Loguercio C, Festi D. Silybin and the liver: from basic research to clinical practice. World J Gastroenterol. 2011 May 14;17(18):2288-301.
  4. Maroni M, Columbi A, Antonini C. "D-glucaric acid urinary excetion as a tool for biological monitoring in occupational medicine." In Brown SS, Davies DS (eds). Organ-directed toxicity: chemical indices and mechanisms. Oxford; Pergamon Press,1981:161-8.
  5. Murata N, Murakami K, Ozawa Y, Kinoshita N, Irie K, Shirasawa T, Shimizu T. Silymarin attenuated the amyloid ? plaque burden and improved behavioral abnormalities in an Alzheimer's disease mouse model. Biosci Biotechnol Biochem. 2010;74(11):2299-306.
  6. Muthumani M, Prabu SM. Silibinin potentially protects arsenic-induced oxidative hepatic dysfunction in rats. Toxicol Mech Methods. 2012 Jan 9. Pradhan SC, Girish C. Hepatoprotective herbal drug, silymarin from experimental pharmacology to clinical medicine. Indian J Med Res. 2006 Nov;124(5):491-504.
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