Bioclinic Naturals NAC And ALA 180 Tablets

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SKU:
14896
UPC:
629022095216
MPN:
BCN-9521
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Description

Bioclinic Naturals NAC And ALA 180 Tablets:

Provides antioxidants for the maintenance of good health. Helps to promote healthy glucose metabolism.

N-acetylcysteine (NAC) and alpha-lipoic acid (ALA) are highly complementary nutrients, critical to cellular function and protection. NAC participates in the synthesis of the cellular antioxidant glutathione, often depleted in diabetes, cardiovascular disease, and those with increased oxidative stress.1,2

ALA, in turn, recycles antioxidant nutrients such as vitamin C and glutathione, and is a cofactor for several mitochondrial enzymes as well as glutathione reductase.7 It supports glycemic control in type 2 diabetics. Its antioxidant and neuroprotective effects may benefit diabetes for neuropathy, neurodegeneration, and a range of oxidant-associated conditions.13,14

Ingredients:

Each 2 Tablet Contain:
N-Acetyl-L-Cysteine
250 mg
Alpha-Lipoic Acid
300 mg

 

Non-medicinal Ingredients: Microcrystalline cellulose, dibasic calcium phosphate dihydrate, stearic acid, vegetable grade magnesium stearate (lubricant), coating (carbohydrate gum [cellulose], glycerin), silica, croscarmellose sodium.

Allergens: Contains no artificial colours, preservatives, or sweeteners; no dairy, starch, sugar, wheat, gluten, yeast, soy, corn, egg, fish, shellfish, salt, tree nuts, or GMOs. Sealed for your protection. Do not use if seal is broken. For freshness, store in a cool, dry place.

Recommended Adult Dose:  2 tablets per day with meals or as directed by a health care practitioner.  

Risk Information:

Contraindications: Consult a health care practitioner prior to use if you are pregnant or breastfeeding, or if you have diabetes or kidney stones. Do not use this product if you are taking antibiotics or vasodilators (dilate the vascular system to treat heart conditions). Avoid use with acetylcysteine allergy, and use with caution in individuals with asthma. Keep out of reach of children.

Interactions:  ALA was shown to prevent drug-induced weight gain associated with atypical antipsychotics without reducing drug efficacy.15 Caution should be used with anti-diabetes medications, as they may have additive hypoglycemic effects. Long term use may warrant low dose copper and/or thiamine supplementation. Although NAC may reduce vasodilators (dilate the vascular system to treat heart conditions) tolerance and improve its efficacy for unstable angina, severe headaches and hypotension may occur. NAC may also reduce the capacity of activated charcoal to absorb acetaminophen.

References:

  1. Rushworth GF1, Megson IL2. Existing and potential therapeutic uses for N-acetylcysteine: the need for conversion to intracellular glutathione for antioxidant benefits. Pharmacol Ther. 2014 Feb;141(2):150-9
  2. Dodd S, Dean O, Copolov DL, Malhi GS, Berk M. N-acetylcysteine for antioxidant therapy: pharmacology and clinical utility. Expert Opin Biol Ther. 2008 Dec;8(12):1955-62.
  3. Lee DH, Lee IK, Song K, Steffes M, et al. A strong dose-response relation between serum concentrations of persistent organic pollutants and diabetes: results from the National Health and Examination Survey 1999-2002. Diabetes Care. 2006 Jul;29(7):1638-44.
  4. Yilmaz H, Sahin S, Sayar N, et al. Effects of folic acid and N-acetylcysteine on plasma homocysteine levels and endothelial function in patients with coronary artery disease. Acta Cardiol. 2007 Dec;62(6):579-85.
  5. Treweeke AT1, Winterburn TJ, Mackenzie I, et al. N-Acetylcysteine inhibits platelet-monocyte conjugation in patients with type 2 diabetes with depleted intraplatelet glutathione: a randomised controlled trial.Diabetologia. 2012 Nov;55(11):2920-8.
  6. Tan KS1, Lee KO, Low KC et al. Glutathione deficiency in type 2 diabetes impairs cytokine responses and control of intracellular bacteria. J Clin Invest. 2012 Jun;122(6):2289-300.
  7. Liu J.The effects and mechanisms of mitochondrial nutrient alpha-lipoic acid on improving age-associated mitochondrial and cognitive dysfunction: an overview. Neurochem Res. 2008 Jan;33(1):194-203.
  8. Xiang G, Pu J, Yue L, et al. α-lipoic acid can improve endothelial dysfunction in subjects with impaired fasting glucose. Metabolism. 2011 Apr;60(4):480-5.
  9. Kamenova P. Improvement of glucose regulating hormone sensitivity in patients with type 2 diabetes mellitus after oral administration of alpha-lipoic acid. Hormones(Athens). 2006 Oct-Dec;5(4):251-8.
  10. Koh EH, Lee WJ, Lee SA, et al. Effects of alpha-lipoic Acid on body weight in obese subjects. Am J Med. 2011 Jan;124(1):85.e1-8.
  11. Han T, Bai J, Liu W, et al. A systematic review and meta-analysis of α-lipoic acid in the treatment of diabetic peripheral neuropathy. Eur J Endocrinol. 2012 Oct;167(4):465-71.
  12. Tang J, et al. Alpha-lipoic acid may improve symptomatic diabetic polyneuropathy. Neurologist. 2007 May;13(3):164-7.
  13. Maczurek A, Hager K, Kenklies M, et al. Lipoic acid as an anti-inflammatory and neuroprotective treatment for Alzheimer's disease. Adv Drug Deliv Rev. 2008 Oct-Nov;60(13-14):1463-70.
  14. Sun YD, Dong YD, Fan R, et al.Effect of (R)-α-lipoic acid supplementation on serum lipids and antioxidative ability in patients with age-related macular degeneration. Ann Nutr Metab. 2012;60(4):293-7.
  15. Kim E, Park DW, et al. A preliminary investigation of alpha-lipoic acid treatment of antipsychotic drug-induced weight gain in patients with schizophrenia. J Clin Psychopharmacol. 2008 Apr;28(2):138-46.
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