Bioclinic Naturals 5-HTP 100 mg 60 Enteric Coated Tablets
Bioclinic Naturals 5-HTP 100 mg 60 Enteric Coated Tablets:
5-Hydroxytryptophan - 100 mg.
Naturally sourced from the seed of plant Griffonia simplicifolia. Unlike L-tryptophan, 5-HTP crosses the blood-brain barrier increasing central nervous system synthesis of serotonin11. It is enteric coated to reduce the likelihood of nausea
5-Hydroxytryptophan (5-HTP) is an amino acid that is the middle step between tryptophan and neurotransmitter serotonin. Scientific evidence indicates that low serotonin levels are linked to a number of common conditions, including depression, obesity, headache/migraine and fibromyalgia. 5-HTP boosts serotonin levels and may offer a benefit in conditions linked to low serotonin levels.1
5-HTP may help patients unresponsive to standard antidepressants may provide equal or if not superior, with fewer side effects.2 Taking 5-HTP can also aid pain syndromes such as migraine and fibromyalgia.3 It is thought both conditions reflect a serotonergic defect. Fibromyalgia suffers have experienced improved symptoms including pain severity, morning stiffness, and sleeplessness with 5-HTP supplementation.3,4,5 5-HTP is known to increase sleep quality, which is critical in those patients suffering from depression or fibromyalgia. In fact, 5-HTP is known to promote and maintain sleep in normal subjects, as well as those experiencing insomnia.6
Research has indicated that 5-HTP may aid weight loss. Early animal studies indicated that genetically obese rats had decreased activity of the enzyme that converts tryptophan to 5-HTP and subsequently serotonin, allowing them to over eat.7 The same mechanism exists in genetically predisposed humans. By providing preformed 5-HTP, this genetic defect is bypassed and more serotonin is manufactured. Human clinical trials have corroborated that 5-HTP is able to reduce caloric intake, promote satiety and induce weight loss without conscious effort by subjects to lose weight.8,9,10
|Medicinal Ingredients Per Each Caplet:|
|L-5-Hydroxytryptophan (Griffonia simplicifolia) (seed)||100 mg|
Non-Medicinal Ingredients: Dibasic calcium phosphate dihydrate, purified water, microcrystalline cellulose, enteric coating (purified water, ethylcellulose, medium chain triglycerides, oleic acid, carbohydrate gum [cellulose], glycerin, sodium alginate, stearic acid), vegetable grade magnesium stearate (lubricant).
Allergens: Contains no artificial colours, preservatives, or sweeteners; no dairy, starch, sugar, wheat, gluten,yeast, soy, corn, egg, fish, shellfish, animal products,salt, tree nuts, or GMOs. Suitable for vegetarians/vegans.
Recommended Adult Dose:
Healthy Mood Balance: 1 caplet 3 times per day with food or as directed by a health care practitioner. To minimize the risk of gastrointestinal side effects, slowly increase up to the full dose over a period of 2 weeks. Use for a minimum of 1 week to see beneficial effects. Consult a health care practitioner for use beyond 1 year.
Sleep Aid: 1 caplet 1–2 times per day with food, 30–45 minutes prior to bedtime, or as directed by a health care practitioner.
Contraindications: Consult a health care practitioner prior to use if you are pregnant or breastfeeding or are taking products with serotonergic activity. Some people may experience diarrhea, nausea, vomiting, abdominal pain or drowsiness. Exercise caution if operating heavy machinery, driving a motor vehicle or involved in activities requiring mental alertness. Discontinue use and consult a health care practitioner if you show signs of weakness, oral ulcers or abdominal pain accompanied by severe muscle pain, if you experience skin changes, or if symptoms persist or worsen. Consult a health care practitioner if sleeplessness persists for more than 3 weeks. Do not use if you have scleroderma. Keep out of reach of children.
Interactions: Combining serotonergic products such as antidepressants, ingredients is standard cough syrups may increase the risk of serotonergic side effects such as serotonin syndrome.12 . The combination of 5-HTP and serotonergic products may result is scleroderma-like skin reactions.13,14 Anecdotally, 5-HTP may lower blood pressure and could be additive to antihypertensive products.
- Birdsall TC. 5-Hydroxytryptophan: a clinically-effective serotonin precursor. Altern Med Rev. 1998;3(4):271-80.
- Poldinger W, Calanchini B, Schwarz W. A functional-dimensional approach to depression: serotonin deficiency as a target syndrome in a comparison of 5-hydroxytryptophan and fluvoxamine. Psychopathology. 1991;24(2):53-81.
- Nicolodi M, Sicuteri F. Fibromyalgia and migraine, two faces of the same mechanism. Serotonin as the common clue for pathogenesis and therapy. Adv Exp Med Biol. 1996;398:373-9.
- Sarzi Puttini P, Caruso I. Primary fibromyalgia syndrome and 5-hydroxy-L-tryptophan: a 90-day open study. J Int Med Res. 1992;20(2):182-9.
- Caruso I, Sarzi Puttini P, Cazzola M, Azzolini V. Double-blind study of 5-hydroxytryptophan versus placebo in the treatment of primary fibromyalgia syndrome. J Int Med Res. 1990 May-Jun;18(3):201-9.
- Wyatt RJ, Zarcone V, Engelman K, Dement WC, Snyder F, Sjoerdsma A. Effects of 5-hydroxytryptophan on the sleep of normal human subjects. Electroencephalogr Clin Neurophysiol. 197 Jun;30(6):505-9.
- Wurtman RJ, Wurtman JJ. Brain serotonin, carbohydrate-craving, obesity and depression. Adv Exp Med Biol. 1996;398:35-41.
- Ceci F, Cangiano C, Cairella M, Cascino A, Del Ben M, Muscaritoli M, Sibilia L, Rossi-Fanelli F. The effects of oral 5-hydroxytryptophan administration on feeding behaviour in obese adult female subjects. J Neural Transm. 1989;76(2):109-117.
- Cangiano C, Ceci F, Cairella M, Cascino A, Del Ben M, Laviano A, Muscaritoli M, Rossi-Fanelli F. Effects of 5-hydroxytryptophan on eating behaviour and adherence to dietary prescriptions in obese adult subjects. Adv Exp Med Biol. 1991;294: 591-593.
- Cangiano C, Ceci F, Cascino A, Del Ben M, Laviano A, Muscaritoli M, Antonucci F, Rossi-Fanelli F. Eating behavior and adherence to dietary prescriptions in obese adult subjects treated with 5-hydroxytryptophan, Am J Clin Nutr. 56: 863-867;1992.
- Shaw K, Turner J, Del Mar C. Tryptophan and 5-hydroxytryptophan for depression. Cochrane Database Syst Rev. 2002;(1):CD003198.
- Singhal AB, Caviness VS, Begleiter AF, Mark EJ, Rordorf G, Koroshetz WJ. Cerebral vasoconstriction and stroke after use of serotonergic drugs. Neurology. 2002 Jan 8;58(1):130-3.
- Sternberg EM, Van Woert MH, Young SN, Magnussen I, Baker H, Gauthier S, Osterland CK. Development of a scleroderma-like illness during therapy with L-5-hydroxytryptophan and serotogenic produts. N Engl J Med. 1980 Oct 2;303(14):782-7.
- Joly P, Lampert A, Thomine E, Lauret P. Development of pseudobullous morphea and scleroderma-like illness during therapy with L-5-hydroxytryptophan and serotogenic products. J Am Acad Dermatol. 1991 Aug;25(2 Pt 1):332-3.