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Aor Sustained Released R Lipoic Acid 90 Tablets

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$47.69
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$38.15 (You save $9.54)
SKU:
18335
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Aor
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Description

Aor Sustained Released R Lipoic Acid 90 Tablets:

R-Alpha Lipoic Acid.

  • Continual cellular protection over 8 hours
  • Fountain of youth antioxidant for longevity
  • AOR was the first in the world to offer sustained release R-lipoic acid

Sustained Release R-Lipoic Acid tablets provide only the natural ‘R’ form of this vital antioxidant, unlike most alpha-lipoic acid supplements which also contain the synthetic, inactive ‘S’ form. R-Lipoic Acid is formulated with advanced sustained release technology to provide continuous antioxidant protection.

Lipoic acid is a versatile antioxidant known for its ability to protect the brain and nerve cells from free radicals and heavy metals that promote cognitive and neurodegenerative diseases. Lipoic acid is known as the “captain of the antioxidants” due to its ability to recycle and recharge other antioxidants such as vitamins C and E. Numerous studies have shown that lipoic acid can balance blood sugar and repair damaged nerves in diabetics. Additionally, this powerful anti-aging nutrient has been shown to mimic some of the effects of caloric restriction, the only proven method of extending health span and lifespan. It does so by protecting the mitochondria, the tiny power plants inside of each of the body’s cells, against free radical damage. Due to its action on the mitochondria it can revive damaged cells, especially those found in nerves and in the liver. It is an ideal partner for glutathione, the most powerful antioxidant produced in the body. Find Aor Supplements at healthpalace.ca

In 2005, AOR introduced the world’s first sustained release pure R-lipoic acid. Unlike most conventional alpha-lipoic acid supplements, AOR’s 95% pure R-lipoic acid delivers the most effective form of this valuable antioxidant without the negative actions of S-lipoic acid. Since lipoic acid has a very short half-life, R SR has been designed to be slowly released into the blood stream over a period of 8 hours. R SR’s new tablet form allows for a better sustained release formula, designed and manufactured by AOR’s research team in our state of the art facility. 

R-Lipoic acid is a powerful, natural and well-rounded antioxidant with many mechanisms of action such as repairing nerves, balancing blood sugar, protecting the brain and increasing energy formation in the mitochondria. The sustained release formula gives you continual antioxidant protection around the clock for many health conditions or for general health and longevity.

Supplement Facts:

Medicinal Ingredients Per 1 Tablet
R(α) lipoic acid (sodium salt)*
150 mg 
*Contains 15 mg sodium per tablet.
Non-medicinal ingredients: sodium stearyl fumarate, xanthan gum. 

AOR guarantees that all ingredients have been declared on the label. Contains no wheat, gluten, corn, nuts, peanuts, sesame seeds, sulphites, mustard, soy, dairy, eggs, fish, shellfish or any animal byproduct. 

Suggested Dose:

(Adult): Take 1 tablet twice daily with/without food, or as directed by a qualified health care practitioner.

Cautions :

Consult a health care practitioner prior to use if you are pregnant or breastfeeding or if you have diabetes. If you experience sweating, paleness, chills, headaches, dizziness and/or confusion, discontinue use and consult a health care practitioner as these may be symptoms of serious low blood sugar.

Source:

Pharmaceutical synthesis

Main Applications:

  • Network antioxidant
  • Mitochondrial function
  • Cognitive support
  • Neurological function
  • Anti-aging
  • Glucose metabolism

An Antioxidant for Macular Degeneration

Age-related macular degeneration (AMD) is thought to be related to oxidative stress. One double-blind, placebo-controlled study found that R-alpha lipoic acid supplementation increased levels of superoxide dismutase (SOD), the main antioxidant in the mitochondria, in subjects with early and intermediate dry AMD. Therefore, it is thought that lipoic acid could help prevent the progression of AMD.

Support for Diabetics on Many Levels

Several recent studies have administered alpha lipoic acid to either type 1 or type 2 diabetic subjects. The longest duration was 6 months with the highest dose at 1200mg/day. The results showed some reduced platelet activity (since platelet activity is typically elevated in diabetes), slightly reduced oxidative stress, increased antioxidant levels (glutathione peroxidase), dose-dependent reduced HbA1c, lower fasting blood glucose, post-prandial blood glucose and insulin resistance, and possibly reduced lipid peroxidation.

Supplementation with a sustained release alpha lipoic acid supplement resulted in sustained decreases in blood glucose that averaged 184mg/dl or just over a 46% decrease.

Diabetic Neuropathy

Another study administered a combination of superoxide dismutase (SOD) with 600mg of alpha-lipoic acid to diabetes mellitus patients with diabetic neuropathy for 4 months. These patients had deficits in both sensory and motor nerve function. The treatment improved both perceived pain and sensory nerve conduction, showing that SOD and ALA might be a feasible treatment for diabetic neuropathy.

A second study examining ALA for diabetic neuropathy administered a high dose of 1800mg (600mg 3x/daily) or a placebo to diabetic patients for 12 weeks. After only 2 weeks, symptoms improved significantly including pain, numbness and burning sensations. These symptoms continued to improve until the end of treatment along with HbA1c. Interestingly, nerve conduction velocity did not improve in this study.

A Meta-analysis reviewed all the clinical trials undertaken for the treatment of diabetic neuropathy with alpha lipoic acid. 1258 diabetic patients were included in the analysis, the largest study population ever used to evaluate the effectiveness of a particular treatment for diabetic neuropathy. The conclusions favored the use of lipoic acid in this population. The analysis revealed that the molecule is an effective treatment for neuropathies and that oral supplementation for 4-7 months reduces neuropathic deficits and improves cardiac neuropathy. It was also clear that Alpha lipoic acid is a well-tolerated and safe treatment.

Other Diabetic Complications

In diabetic rats, alpha lipoic acid reduces growth retardation and congenital anomalies in fetuses, supporting the theory that reactive oxygen species are linked to embryonic malformations. Animal studies have shown that in a high fructose diet, lipoic acid helps maintain the function of the antioxidant system and lowers lipid peroxidation and insulin resistance.Find Aor Supplements at healthpalace.ca

Inflammation

How does lipoic acid help reduce inflammation? Alpha lipoic acid is thought to reduce oxidation and inflammation by mediating the cyclic AMP/ protein kinase A cascade. ALA has been shown to suppress NK cell (natural killer cell) activation and cytotoxicity and reduce IL-6, IL-17 and T-cell activation. When 1200mg of ALA were given to MS (multiple sclerosis) patients, cAMP did indeed increase.

Boosts Glutathione

Studies in older rats have shown that glutathione levels drop significantly with age. Glutathione is a powerful free radical scavenger and the major antioxidant species found in cells. Drops in glutathione levels in older rats reached 58% in the heart and 66% in the brain in comparison to younger counterparts. Lipoic acid supplementation increased glutathione levels in the aging brain.

Mitochondrial Dysfunction & Parkinson’s Disease

One very interesting cell culture study found that R-lipoic acid prevented GSH (glutathione) loss and subsequently prevented impaired function of mitochondrial complex I, which usually go hand in hand. This is relevant because oxidative stress is thought to play a role in Parkinson’s disease. Oxidative stress is aggravated with decreased levels of glutathione, which can result in mitochondrial dysfunction and therefore cellular dysfunction and cell death in the neurons in the substantia nigra, the area most affected in Parkinson’s disease.Find Aor Supplements at healthpalace.ca

Liver Protection

In another experiment, liver cells isolated from young and older rats were used to see the effectiveness of alpha lipoic acid at preventing liver injury. Total glutathione cellular levels were 37.7% lower in older rats. (R )-lipoic acid significantly protected the hepatocytes against Butylhydroperoxide (an oxidative stress inducing agent) both in vitro and in vivo. The results suggest that ALA is indicated in liver conditions where oxidative stress confers pathology such as alcoholic liver disease and viral hepatitis. ALA was also shown to protect against cadmium-induced hepatotoxicity in animals.

References:

  1. Al Ghafli MH, Padmanabhan R, Kataya HH, Berg B. Effects of alpha-lipoic acid supplementation on maternal diabetes-induced growth retardation and congenital anomalies in rat fetuses. Mol Cell Biochem. 2004 Jun;261(1-2):123-35.
  2. Bustamante J, Lodge JK, Marcocci L, Tritschler HJ, Packer L, Rihn BH. Alpha-lipoic acid in liver metabolism and disease. Free Radic Biol Med. 1998 Apr;24(6):1023-39. Review.
  3. Hagen TM, Vinarsky V, Wehr CM, Ames BN. (R)-alpha-lipoic acid reverses the age-associated increase in susceptibility of hepatocytes to tert-butylhydroperoxide both in vitro and in vivo. Antioxid Redox Signal. 2000 Fall;2(3):473-83.
  4. Hagen TM, Ingersoll RT, Lykkesfeldt J, Liu J, Wehr CM, Vinarsky V, Bartholomew JC, Ames AB. (R)-alpha-lipoic acid-supplemented old rats have improved mitochondrial function, decreased oxidative damage, and increased metabolic rate. FASEB J. 1999 Feb;13(2):411-8.
  5. Hendler SS, Rorvik D (2001). Physicians’ Desk Reference for Nutritional Supplements. New Jersey: Thompson PDR
  6. Huerta AE, Navas-Carretero S, Prieto-Hontoria PL, Martínez JA, Moreno-Aliaga MJ. Effects of α-lipoic acid and eicosapentaenoic acid in overweight and obese women during weight loss. Obesity (Silver Spring). 2014 Dec 31. 
  7. Jellin JM, Gregory P, Batz F, Hitchens K, et al. Pharmacist’s Letter/ Prescriber’s Letter Natural Medicines Comprehensive Database. 3rd ed. Stockton, CA: Therapeutic Research Faculty; 2000
  8. McNeilly AM, Davison GW, Murphy MH, Nadeem N, Trinick T, Duly E, Novials A, McEneny J. Effect of α-lipoic acid and exercise training on cardiovascular disease risk in obesity with impaired glucose tolerance. Lipids Health Dis. 2011 Nov 22;10:217.
  9. Packer L, Kraemer K, Rimbach G. Molecular aspects of lipoic acid in the prevention of diabetes complications. Nutrition. 2001 Oct;17(10):888-95. Review. 
  10. Suh JH, Wang H, Liu RM, Liu J, Hagen TM. (R)-alpha-lipoic acid reverses the age-related loss in GSH redox status in post-mitotic tissues: evidence for increased cysteine requirement for GSH synthesis. Arch Biochem Biophys. 2004 Mar 1;423(1):126-35.
  11. Suh JH, Shigeno ET, Morrow JD, Cox B, Rocha AE, Frei B, Hagen TM. Oxidative stress in the aging rat heart is reversed by dietary supplementation with (R)-(alpha)-lipoic acid. FASEB J. 2001 Mar;15(3):700-6.

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