Aor BioFolate 30 Veg Capsules

AOR BioFolate 30 Veg Capsules:

Helps to prevent folate deficiency. Helps the body form red blood cells. Helps to maintain the body's ability to metabolize nutrients. It Provides Folate in a Biologically Active Form.

BioFolate contains the preferred, biologically active form of folate that is produced in the body. Folic acid (or folate) is a water-soluble vitamin that plays a key role in the biosynthesis of DNA and RNA, red blood cell production and the metabolization of proteins. Folic acid is also necessary for genome maintenance, the regulation of gene expression, and other functions. Natural folates are found in dark green leafy vegetables (spinach, kale, mustard greens, turnip greens) as well as oranges, broccoli, cauliflower, liver and brewer’s yeast. The absorption efficiency of natural folates is approximately 50% that of supplemental folic acid. This is because natural food folates are pteroylpolyglutamate derivatives. These require cleavage (by an enzyme called folate conjugase) to pteroylmonoglutamate forms prior to absorption from the small intestine.

A deficiency in dietary folate has wide-ranging implications over and above the risk of aforementioned neural tube defects among expectant and potential mothers. Such implications can include weakness, fatigue, irritability, headaches, difficulties in cognitive function, cramps, palpitations, shortness of breath and atrophic glossitis.

Low folate levels are linked to elevated serum homocysteine concentration, hypersegmentation of the neutrophils, and decreased hemogloblin and erythrocyte concentrations. Folate deficiencies have also been linked to increased risks of cardiovascular disease, abnormal cell growth, altered cognitive function and mood. Folic acid’s critical role in converting homocysteine back to methionine gives it the potential to address many of the myriad of health conditions that are initiated by high homocysteine levels. Folate supplementation appears to help reduce plasma homocysteine levels in a dose-dependent fashion.

High-dose folic acid supplementation (10 mg daily for two weeks) may help prevent some of the deleterious effects of triglyceride-rich lipoproteins on endothelium-dependent vasodilation in healthy volunteers challenged with an acute oral fat load. Folic acid intake was significantly inversely associated with multiple indices of oxidized LDL-cholesterol. This correlation remained significant even when adjusted for potential confounding variables, including consumption of other vitamins and nutrients.

A number of conditions can lead to folate deficiency. Chronic alcohol users can become deficient in the vitamin due in part to ethanol’s impairment of folate absorption and hepatobiliary metabolism, as well as to increased renal folate excretion caused by ethanol. Crohn’s disease, amyloidosis of the small intestine, diabetic enteropathy, and tropical and non-tropical sprue (gluten-sensitive enteropathy) can also result in folate deficiency. Some conditions or situations such as chronic hemolytic anemias (e.g., sickle cell disease), chronic hemodialysis, peritoneal dialysis, chronic exfoliative skin disorders and of course pregnancy, all cause an increased demand for folate.

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